SAMPLE PREPARATION 1 - Collection: In-line On-line or at-line Off-line 2 - Preservation: None Chemical or physical Physico-chemical 3 - Transport: None Required 4 - Storage: None Under normal conditions Under special conditions 5 - Type of method: No sample preparation Simple procedures, e.g., filtration, decantation Extraction required 6 - Scale of extraction: Nano-extraction Micro-extraction Macro-extraction Not applicable 7 - Solvents/reagents used: Solvent-free methods Green solvents/reagents used Non-green solvents/reagents used 8 - Additional treatment: None Simple treatments (clean up, solvent removal, etc.) Advanced treatments (derivatization, mineralization, etc.) REAGENT AND SOLVENTS 9 - Amount: < 10 mL (< 10 g) 10–100 mL (10–100 g) > 100 mL (> 100 g) 10 - Health hazard: Slightly toxic, slight irritant; NFPA health hazard score = 0 or 1 Moderately toxic; could cause temporary incapacitation; NFPA = 2 or 3 Serious injury on short-term exposure; known or suspected small animal carcinogen; NFPA = 4 11 - Safety hazard: Highest NFPA flammability or instability score of 0 or 1. No special hazards Highest NFPA flammability or instability score of 2 or 3, or a special hazard is used Highest NFPA flammability or instability score of 4 INSTRUMENTATION 12 - Energy: ≤0.1 kWh per sample ≤1.5 kWh per sample > 1.5 kWh per sample 13 - Occupational hazard: Hermetic sealing of analytical process Emission of vapors to the atmosphere 14 - Waste: < 1 mL (< 1 g) 1–10 mL (1–10 g) > 10 mL (> 10 g) 15 - Waste treatment: Recycling Degradation, passivation No treatment 16 - QUANTIFICATION: Yes No YIELD AND CONDITIONS I - Yield: Not applicable >89% 70–89% <70% II - Temperature/time: Not applicable Room temperature, <1 h Room temperature, >1 h, Heating, <1 h, Cooling to 0°C Heating, >1 h, Cooling <0°C RELATION TO GREEN ECONOMY III - Number of rules met: 5-6 3-4 1-2 REAGENTS AND SOLVENTS IVa - Health hazard: Slightly toxic, slight irritant; NFPA health hazard score of 0 or 1 Moderately toxic; could cause temporary incapacitation; NFPA = 2 or 3 Serious injury on short-term exposure; known or suspected small animal carcinogen; NFPA = 4 IVb - Safety hazard: Highest NFPA flammability, instability score of 0 or 1. No special hazards Highest NFPA flammability or instability score is 2 or 3, or a special hazard is involved Highest NFPA flammability or instability score is 4 INSTRUMENTATION Va - Technical setup: Common setup Additional setups/semi-advanced instruments used Pressure equipment >1 atm; glove box Vb - Energy: ≤0.1 kWh per sample ≤1.5 kWh per sample >1.5 kWh per sample Vc - Occupational hazard: Hermetization of the analytical process Emission of vapors to the atmosphere WORKUP AND PURIFICATION VIa - Workup and purification of the end product: Not applicable None or simple processes Application of standard purification techniques Application of advanced purification techniques VIb - Purity: Not applicable >98% 97–98% <97% 27. E-FACTOR This application is for research purposes. Cite this work as: F.R. Mansour, K.M. Omer, J. Płotka-Wasylka, A total scoring system and software for complex modified GAPI (ComplexMoGAPI) application in the assessment of method greenness, Green Anal. Chem. 10 (2024) 100126.doi:10.1016/j.greeac.2024.100126 .
